Doublecortin (Phospho Ser378) Polyclonal Antibody

产品详情

产品名称

Doublecortin (Phospho Ser378) Polyclonal Antibody

产品货号

YM-A16187

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

IHC,IF,WB

分子量

44kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

IHC 1:50-200;WB 1:500-2000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from human Doublecortin (Phospho-Ser378)

特异性

This antibody detects endogenous phospho levels of Doublecortin (Phospho-Ser378) at Human:S378, Mouse:S297, Rat:S297

基因名称

DCX DBCN LISX

蛋白名称

Doublecortin (Phospho-Ser378)

别名

Neuronal migration protein doublecortin;Doublin;Lissencephalin-X;Lis-X;

基因ID-1

1641

SwissProt

O43602

背景

This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain&quo

细胞定位

Cytoplasm . Cell projection, neuron projection . Localizes at neurite tips. .