MLKL (phospho Ser358) Polyclonal Antibody

产品详情

产品名称

MLKL (phospho Ser358) Polyclonal Antibody

产品货号

YM-A16188

规格

50μL;100μL

种属反应

Human

实验应用

IHC,IF

分子量

55kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

IHC 1:100-500;IF/ICC1:100-500

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from human MLKL (phospho S358)

特异性

This antibody detects endogenous phospho levels of MLKL (phospho S358) at Human, Mouse, Rat

基因名称

MLKL

蛋白名称

MLKL (phospho S358)

别名

Mixed lineage kinase domain-like protein

基因ID-1

197259

SwissProt

Q8NB16

背景

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],

细胞定位

Cytoplasm . Cell membrane . Nucleus . Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671). Localizes to the nucleus in response to orthomyxoviruses infection (By similarity). .