53BP1 (Phospho Ser1618) rabbit pAb

产品详情

产品名称

53BP1 (Phospho Ser1618) rabbit pAb

产品货号

YM-A16196

规格

50μL;100μL

种属反应

Human,Rat

实验应用

WB

分子量

213kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:1000-2000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized phosho peptide around human 53BP1 (Ser1618)

特异性

This antibody detects endogenous levels of Human Rat 53BP1 (phospho-Ser1618)

基因名称

TP53BP1

蛋白名称

53BP1 (Ser1618)

别名

Tumor suppressor p53-binding protein 1;53BP1;p53-binding protein 1;p53BP1;

基因ID-1

7158

SwissProt

Q12888

背景

细胞定位

Nucleus . Chromosome . Chromosome, centromere, kinetochore . Localizes to the nucleus in absence of DNA damage (PubMed:28241136). Following DNA damage, recruited to sites of DNA damage, such as double stand breaks (DSBs): recognizes and binds histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23333306, PubMed:23760478, PubMed:24703952, PubMed:28241136, PubMed:17190600). Associated with kinetochores during mitosis (By similarity). .