BMAL1 (Phospho Ser42) rabbit pAb

产品详情

产品名称

BMAL1 (Phospho Ser42) rabbit pAb

产品货号

YM-A16221

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB

分子量

69kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:1000-2000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized phosho peptide around human BMAL1 (Ser42)

特异性

This antibody detects endogenous levels of Human Mouse Rat BMAL1 (phospho-Ser42)

基因名称

ARNTL BHLHE5 BMAL1 MOP3 PASD3

蛋白名称

BMAL1 (Ser42)

别名

Aryl hydrocarbon receptor nuclear translocator-like protein 1;Basic-helix-loop-helix-PAS protein MOP3;Brain and muscle ARNT-like 1;Class E basic helix-loop-helix protein 5;bHLHe5;Member of PAS protein 3;PAS domain-containing protein 3;bHLH-PAS protein JAP3;

基因ID-1

406

SwissProt

O00327

背景

The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014],

细胞定位

Nucleus . Cytoplasm . Nucleus, PML body . Shuttles between the nucleus and the cytoplasm and this nucleocytoplasmic shuttling is essential for the nuclear accumulation of CLOCK, target gene transcription and the degradation of the CLOCK-ARNTL/BMAL1 heterodimer. The sumoylated form localizes in the PML body. Sequestered to the cytoplasm in the presence of ID2. .