GIT2 (Phospho Tyr592) rabbit pAb

产品详情

产品名称

GIT2 (Phospho Tyr592) rabbit pAb

产品货号

YM-A16283

规格

50μL;100μL

种属反应

Human,Rat,Mouse,

实验应用

WB

分子量

84kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:1000-2000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized phosho peptide around human GIT2 (Tyr592)

特异性

This antibody detects endogenous levels of Human GIT2 (phospho-Tyr592)

基因名称

GIT2 KIAA0148

蛋白名称

GIT2 (Tyr592)

别名

ARF GTPase-activating protein GIT2;ARF GAP GIT2;Cool-interacting tyrosine-phosphorylated protein 2;CAT-2;CAT2;G protein-coupled receptor kinase-interactor 2;GRK-interacting protein 2;

基因ID-1

9815

SwissProt

Q14161

背景

This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G

细胞定位

nucleoplasm,focal adhesion,