NEDD4L (Phospho Ser448) rabbit pAb

产品详情

产品名称

NEDD4L (Phospho Ser448) rabbit pAb

产品货号

YM-A16346

规格

50μL;100μL

种属反应

Human,Rat,Mouse,

实验应用

WB

分子量

110-120kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:1000-2000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized phosho peptide around human NEDD4L (Ser448)

特异性

This antibody detects endogenous levels of Human NEDD4L (phospho-Ser448)

基因名称

NEDD4L KIAA0439 NEDL3

蛋白名称

NEDD4L (Ser448)

别名

E3 ubiquitin-protein ligase NEDD4-like;NEDD4.2;Nedd4-2;

基因ID-1

23327

SwissProt

Q96PU5

背景

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012],

细胞定位

Cytoplasm . Golgi apparatus . Endosome, multivesicular body . May be recruited to exosomes by NDFIP1.