Rb (Phospho Ser807/811) rabbit pAb

产品详情

产品名称

Rb (Phospho Ser807/811) rabbit pAb

产品货号

YM-A16382

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,IHC

分子量

106kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-2000;IHC 1:50-300

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized phosho peptide around human Rb (Ser807 and 811)

特异性

This antibody detects endogenous levels of Human Mouse Rat Rb (phospho-Ser807 or 811)

基因名称

RB1

蛋白名称

Rb (Ser807/811)

别名

Retinoblastoma-associated protein;p105-Rb;pRb;Rb;pp110;

基因ID-1

5925

SwissProt

P06400

背景

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008],

细胞定位

Nucleus . During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization. .