Rev-erbα (Phospho Ser55/59) rabbit pAb

产品详情

产品名称

Rev-erbα (Phospho Ser55/59) rabbit pAb

产品货号

YM-A16385

规格

50μL;100μL

种属反应

Human,Rat,Mouse,

实验应用

WB,IHC

分子量

67kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-2000;IHC 1:50-300

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized phosho peptide around human Rev-erbα (Ser55 and 59)

特异性

This antibody detects endogenous levels of Human Rev-erbα (phospho-Ser55 or 59)

基因名称

NR1D1 EAR1 HREV THRAL

蛋白名称

Rev-erbα (Ser55/59)

别名

Nuclear receptor subfamily 1 group D member 1;Rev-erbA-alpha;V-erbA-related protein 1;EAR-1;

基因ID-1

9572

SwissProt

P20393

背景

This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013],

细胞定位

Nucleus . Cytoplasm . Cell projection, dendrite . Cell projection, dendritic spine . Localizes to the cytoplasm, dendrites and dendritic spine in the presence of OPHN1. Localizes predominantly to the nucleus at ZT8 whereas it is cytoplasmic at ZT20. Phosphorylation by CSNK1E enhances its cytoplasmic localization. .