Stat5 (Phospho Tyr694) rabbit pAb

产品详情

产品名称

Stat5 (Phospho Tyr694) rabbit pAb

产品货号

YM-A16428

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,IHC

分子量

90kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-2000;IHC 1:50-300

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized phosho peptide around human Stat5 (Tyr694)

特异性

This antibody detects endogenous levels of Human Mouse Stat5 (phospho-Tyr694)

基因名称

STAT5B

蛋白名称

Stat5 (Tyr694)

别名

Signal transducer and activator of transcription 5B

基因ID-1

6777

SwissProt

P51692

背景

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provi

细胞定位

Cytoplasm . Nucleus . Translocated into the nucleus in response to phosphorylation. .