14-3-3σ (Phospho Ser186) rabbit pAb

产品详情

产品名称

14-3-3σ (Phospho Ser186) rabbit pAb

产品货号

YM-A16518

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,ELISA

分子量

30kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:1000-2000;ELISA 1:5000-20000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from human 14-3-3σ (Phospho Ser186)

特异性

This antibody detects endogenous levels of Human,Mouse 14-3-3σ (Phospho Ser186)

基因名称

SFN HME1

蛋白名称

14-3-3σ (Phospho Ser186)

别名

14-3-3 protein sigma;Epithelial cell marker protein 1;Stratifin;

基因ID-1

2810

SwissProt

P31947

背景

function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway.,function:p53-regulated inhibitor of G2/M progression.,similarity:Belongs to the 14-3-3 family.,subcellular location:May be secreted by a non-classical secretory pathway.,subunit:Homodimer. Interacts with KRT17 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN.,tissue specificity:Present mainly in tissues enriched in stratified squamous keratinising epithelium.,

细胞定位

Cytoplasm. Nucleus . Secreted. May be secreted by a non-classical secretory pathway.