FGF Receptor 2 (Phospho Ser782) rabbit pAb

产品详情

产品名称

FGF Receptor 2 (Phospho Ser782) rabbit pAb

产品货号

YM-A16561

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB

分子量

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-2000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from human FGFR2 (Phospho-Ser782)

特异性

This antibody detects endogenous levels of FGFR2 (Phospho-Ser782) at Human, Mouse,Rat

基因名称

FGFR2 BEK KGFR KSAM

蛋白名称

FGFR2 (Phospho-Ser782)

别名

Fibroblast growth factor receptor 2;FGFR-2;K-sam;KGFR;Keratinocyte growth factor receptor;CD antigen CD332;

基因ID-1

2263

SwissProt

P21802

背景

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, C

细胞定位

Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Cytoplasmic vesicle. Detected on osteoblast plasma membrane lipid rafts. After ligand binding, the activated receptor is rapidly internalized and degraded.; [Isoform 1]: Cell membrane; Single-pass type I membrane protein. After ligand binding, the activated receptor is rapidly internalized and degraded.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein. After ligand binding, the activated receptor is rapidly internalized and degraded.; [Isoform 8]: Secreted.; [Isoform 13]: Secreted.