Rad2/FEN1 (Phospho Ser187) rabbit pAb

产品详情

产品名称

Rad2/FEN1 (Phospho Ser187) rabbit pAb

产品货号

YM-A16617

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB

分子量

42kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-2000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from human Rad2/FEN1 (Phospho-Ser187)

特异性

This antibody detects endogenous levels of Rad2/FEN1 (Phospho-Ser187) at Human, Mouse,Rat

基因名称

FEN1 RAD2

蛋白名称

Rad2/FEN1 (Phospho-Ser187)

别名

Flap endonuclease 1;FEN-1;DNase IV;Flap structure-specific endonuclease 1;Maturation factor 1;MF1;hFEN-1;

基因ID-1

2237

SwissProt

P39748

背景

The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions

细胞定位

[Isoform 1]: Nucleus, nucleolus. Nucleus, nucleoplasm. Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.; [Isoform FENMIT]: Mitochondrion .