ATM (Phospho Ser367) Rabbit pAb

产品详情

产品名称

ATM (Phospho Ser367) Rabbit pAb

产品货号

YM-A16706

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

IHC,WB

分子量

350kD

宿主

Rabbit

同种型

修饰

Phospho

推荐稀释比

WB 1:500-2000;IHC 1:50-200

组成

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from human ATM (Phospho Ser367)

特异性

This antibody detects endogenous levels of ATM (Phospho Ser367) Rabbit pAb at Human, Mouse

基因名称

ATM

蛋白名称

Serine-protein kinase ATM (Ataxia telangiectasia mutated) (A-T mutated)

别名

Serine-protein kinase ATM;Ataxia telangiectasia mutated;A-T mutated;

基因ID-1

472

SwissProt

Q13315

背景

ATM serine/threonine kinase(ATM) Homo sapiens The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010],

细胞定位

Nucleus . Cytoplasmic vesicle . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Primarily nuclear. Found also in endocytic vesicles in association with beta-adaptin. .