FKHRL1 (Phospho Ser321) Rabbit pAb

产品详情

产品名称

FKHRL1 (Phospho Ser321) Rabbit pAb

产品货号

YM-A16730

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

IHC,WB

分子量

71kD

宿主

Rabbit

同种型

修饰

Phospho

推荐稀释比

WB 1:500-2000;IHC 1:50-200

组成

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from human FKHRL1 (Phospho Ser321)

特异性

This antibody detects endogenous levels of FKHRL1 (Phospho Ser321) Rabbit pAb at Human, Mouse

基因名称

FOXO3 FKHRL1 FOXO3A

蛋白名称

Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1)

别名

Forkhead box protein O3;AF6q21 protein;Forkhead in rhabdomyosarcoma-like 1;

基因ID-1

2309

SwissProt

O43524

背景

forkhead box O3(FOXO3) Homo sapiens This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008],

细胞定位

Cytoplasm, cytosol . Nucleus . Mitochondrion matrix . Mitochondrion outer membrane ; Peripheral membrane protein ; Cytoplasmic side . Retention in the cytoplasm contributes to its inactivation (PubMed:10102273, PubMed:15084260, PubMed:16751106). Translocates to the nucleus upon oxidative stress and in the absence of survival factors (PubMed:10102273, PubMed:16751106). Translocates from the cytosol to the nucleus following dephosphorylation in response to autophagy-inducing stimuli (By similarity). Translocates in a AMPK-dependent manner into the mitochondrion in response to metabolic stress (PubMed:23283301, PubMed:29445193). Serum deprivation increases localization to the nucleus, leading to activate expression of SOX9 and subsequent chondrogenesis (By similarity). .