FGFR3 (Phospho Tyr577) Rabbit pAb

产品详情

产品名称

FGFR3 (Phospho Tyr577) Rabbit pAb

产品货号

YM-A16741

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

IHC,WB

分子量

95kD

宿主

Rabbit

同种型

修饰

Phospho

推荐稀释比

WB 1:500-2000;IHC 1:50-200

组成

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from human FGFR3 (Phospho Tyr577)

特异性

This antibody detects endogenous levels of FGFR3 (Phospho Tyr577) Rabbit pAb at Human, Mouse

基因名称

FGFR3 JTK4

蛋白名称

Fibroblast growth factor receptor 3 (FGFR-3) (CD antigen CD333)

别名

Fibroblast growth factor receptor 3;FGFR-3;CD antigen CD333;

基因ID-1

2261

SwissProt

P22607

背景

fibroblast growth factor receptor 3(FGFR3) Homo sapiens This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dys

细胞定位

[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Endoplasmic reticulum. The activated receptor is rapidly internalized and degraded. Detected in intracellular vesicles after internalization of the autophosphorylated receptor.; [Isoform 2]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 3]: Secreted.; [Isoform 4]: Cell membrane ; Single-pass type I membrane protein .