Androgen Receptor (Phospho Tyr534) Rabbit pAb

产品详情

产品名称

Androgen Receptor (Phospho Tyr534) Rabbit pAb

产品货号

YM-A16755

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

IHC,WB

分子量

宿主

Rabbit

同种型

修饰

Phospho

推荐稀释比

WB 1:500-2000;IHC 1:50-200

组成

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from human Androgen Receptor (Phospho Tyr534)

特异性

This antibody detects endogenous levels of Androgen Receptor (Phospho Tyr534) Rabbit pAb at Human, Mouse,Rat

基因名称

AR DHTR NR3C4

蛋白名称

Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)

别名

Androgen receptor;Dihydrotestosterone receptor;Nuclear receptor subfamily 3 group C member 4;

基因ID-1

367

SwissProt

P10275

背景

androgen receptor(AR) Homo sapiens The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoform

细胞定位

Nucleus . Cytoplasm . Detected at the promoter of target genes (PubMed:25091737). Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of RACK1. .