AKAP 13 Polyclonal Antibody

产品详情

产品名称

AKAP 13 Polyclonal Antibody

产品货号

YM-A16920

规格

50μL;100μL

种属反应

Human,Rat,Mouse,

实验应用

WB,IHC,IF,ELISA

分子量

307kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human AKAP13. AA range:721-770

特异性

AKAP 13 Polyclonal Antibody detects endogenous levels of AKAP 13 protein.

基因名称

AKAP13

蛋白名称

A-kinase anchor protein 13

别名

AKAP13;BRX;HT31;LBC;A-kinase anchor protein 13;AKAP-13;AKAP-Lbc;Breast cancer nuclear receptor-binding auxiliary protein;Guanine nucleotide exchange factor Lbc;Human thyroid-anchoring protein 31;Lymphoid blast crisis oncogene;LBC

基因ID-1

11214

SwissProt

Q12802

背景

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addi

细胞定位

Cytoplasm, cytosol . Cytoplasm . Cytoplasm, cell cortex . Nucleus . Membrane ; Peripheral membrane protein . Colocalizes with the actin cytoskeleton at the cell cortex. .