Apaf-1-ALT Polyclonal Antibody

产品详情

产品名称

Apaf-1-ALT Polyclonal Antibody

产品货号

YM-A16990

规格

50μL;100μL

种属反应

Human,Rat,Mouse,

实验应用

WB,IHC,IF,ELISA

分子量

27kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human APAF-1-ALT. AA range:289-338

特异性

Apaf-1-ALT Polyclonal Antibody detects endogenous levels of Apaf-1-ALT protein.

基因名称

APAF1

蛋白名称

Apoptotic protease-activating factor 1

别名

APAF1-interacting protein;APIP;APIP2;CGI-29 protein;MMRP19;dJ179L10.2;likely ortholog of mouse monocyte macrophage 19

基因ID-1

317

SwissProt

O14727-6

背景

This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

细胞定位

Cytoplasm .