APLP-2 Polyclonal Antibody

产品详情

产品名称

APLP-2 Polyclonal Antibody

产品货号

YM-A17000

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,IHC,IF,ELISA

分子量

90-120kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:40000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human APLP2. AA range:241-290

特异性

APLP-2 Polyclonal Antibody detects endogenous levels of APLP-2 protein.

基因名称

APLP2

蛋白名称

Amyloid-like protein 2

别名

APLP2;APPL2;Amyloid-like protein 2;APLP-2;APPH;Amyloid protein homolog;CDEI box-binding protein;CDEBP

基因ID-1

334

SwissProt

Q06481

背景

This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011],

细胞定位

Cell membrane ; Single-pass type I membrane protein . Nucleus .