Arkadia Polyclonal Antibody

产品详情

产品名称

Arkadia Polyclonal Antibody

产品货号

YM-A17056

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,ELISA

分子量

110kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;ELISA 1:40000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human RNF111. AA range:901-950

特异性

Arkadia Polyclonal Antibody detects endogenous levels of Arkadia protein.

基因名称

RNF111

蛋白名称

E3 ubiquitin-protein ligase Arkadia

别名

RNF111;E3 ubiquitin-protein ligase Arkadia;RING finger protein 111

基因ID-1

54778

SwissProt

Q6ZNA4

背景

ring finger protein 111(RNF111) Homo sapiens The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012],

细胞定位

Nucleus . Cytoplasm . Nucleus, PML body . Upon TGF-beta treatment, translocates from nucleus to cytosol. .