Atg4D Polyclonal Antibody

产品详情

产品名称

Atg4D Polyclonal Antibody

产品货号

YM-A17121

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,IHC,IF,ELISA

分子量

45kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:5000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from the Internal region of human Atg4D.

特异性

Atg4D Polyclonal Antibody detects endogenous levels of Atg4D protein.

基因名称

ATG4D

蛋白名称

Cysteine protease ATG4D

别名

ATG4D;APG4D;AUTL4;Cysteine protease ATG4D;AUT-like 4 cysteine endopeptidase;Autophagin-4;Autophagy-related cysteine endopeptidase 4;Autophagy-related protein 4 homolog D

基因ID-1

84971

SwissProt

Q86TL0

背景

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],

细胞定位

[Cysteine protease ATG4D]: Cytoplasm .; [Cysteine protease ATG4D, mitochondrial]: Cytoplasm . Mitochondrion matrix . Imported into mitochondrial matrix after cleavage by CASP3 during oxidative stress and cell death. .