AVP Receptor V2 Polyclonal Antibody

产品详情

产品名称

AVP Receptor V2 Polyclonal Antibody

产品货号

YM-A17148

规格

50μL;100μL

种属反应

Human,Rat,Mouse,

实验应用

WB,IF,ELISA

分子量

38kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human AVPR2. AA range:72-121

特异性

AVP Receptor V2 Polyclonal Antibody detects endogenous levels of AVP Receptor V2 protein.

基因名称

AVPR2

蛋白名称

Vasopressin V2 receptor

别名

AVPR2;ADHR;DIR;DIR3;V2R;Vasopressin V2 receptor;V2R;AVPR V2;Antidiuretic hormone receptor;Renal-type arginine vasopressin receptor

基因ID-1

554

SwissProt

P30518

背景

This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus

细胞定位

Cell membrane ; Multi-pass membrane protein .