BUB1 Polyclonal Antibody

产品详情

产品名称

BUB1 Polyclonal Antibody

产品货号

YM-A17252

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,ELISA

分子量

120kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;ELISA 1:40000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human BUB1. AA range:781-830

特异性

BUB1 Polyclonal Antibody detects endogenous levels of BUB1 protein.

基因名称

BUB1

蛋白名称

Mitotic checkpoint serine/threonine-protein kinase BUB1

别名

BUB1;BUB1L;Mitotic checkpoint serine/threonine-protein kinase BUB1;hBUB1;BUB1A

基因ID-1

699

SwissProt

O43683

背景

This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],

细胞定位

Nucleus. Chromosome, centromere, kinetochore. Nuclear in interphase cells. Accumulates gradually during G1 and S phase of the cell cycle, peaks at G2/M, and drops dramatically after mitosis. Localizes to the outer kinetochore. Kinetochore localization is required for normal mitotic timing and checkpoint response to spindle damage and occurs very early in prophase. AURKB, KNL1 and INCENP are required for kinetochore localization (By similarity). .