CARD 11 Polyclonal Antibody

产品详情

产品名称

CARD 11 Polyclonal Antibody

产品货号

YM-A17333

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,IHC,IF,ELISA

分子量

130kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:40000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human CARD11. AA range:10-59

特异性

CARD 11 Polyclonal Antibody detects endogenous levels of CARD 11 protein.

基因名称

CARD11

蛋白名称

Caspase recruitment domain-containing protein 11

别名

CARD11;CARMA1;Caspase recruitment domain-containing protein 11;CARD-containing MAGUK protein 1;Carma 1

基因ID-1

84433

SwissProt

Q9BXL7

背景

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008],

细胞定位

Cytoplasm . Membrane raft . Colocalized with DPP4 in membrane rafts. .