CD30-L Polyclonal Antibody

产品详情

产品名称

CD30-L Polyclonal Antibody

产品货号

YM-A17422

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,IF,ELISA

分子量

30kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human CD153. AA range:71-120

特异性

CD30-L Polyclonal Antibody detects endogenous levels of CD30-L protein.

基因名称

TNFSF8

蛋白名称

Tumor necrosis factor ligand superfamily member 8

别名

TNFSF8;CD30L;CD30LG;Tumor necrosis factor ligand superfamily member 8;CD30 ligand;CD30-L;CD antigen CD153

基因ID-1

2965

SwissProt

P32971

背景

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011],

细胞定位

Membrane; Single-pass type II membrane protein.