Cdc14a phosphatase Polyclonal Antibody

产品详情

产品名称

Cdc14a phosphatase Polyclonal Antibody

产品货号

YM-A17452

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,ELISA

分子量

66kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;ELISA 1:20000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from the Internal region of human Cdc14a phosphatase.

特异性

Cdc14a phosphatase Polyclonal Antibody detects endogenous levels of Cdc14a phosphatase protein.

基因名称

CDC14A

蛋白名称

Dual specificity protein phosphatase CDC14A

别名

CDC14A;Dual specificity protein phosphatase CDC14A;CDC14 cell division cycle 14 homolog A

基因ID-1

8556

SwissProt

Q9UNH5

背景

cell division cycle 14A(CDC14A) Homo sapiens The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008],

细胞定位

Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, spindle . Cell projection, kinocilium . Cell projection, stereocilium . Centrosomal during interphase, released into the cytoplasm at the onset of mitosis. Subsequently localizes to the mitotic spindle pole and at the central spindle (PubMed:12134069, PubMed:11901424, PubMed:15263015). Present along both the transient kinocilia of developing cochlear hair cells and the persistent kinocilia of vestibular hair cells (By similarity). .