c-Fgr Polyclonal Antibody

产品详情

产品名称

c-Fgr Polyclonal Antibody

产品货号

YM-A17527

规格

50μL;100μL

种属反应

Human,Rat,Mouse,

实验应用

WB,IHC,IF,ELISA

分子量

50kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:40000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human c-ternal FGR. AA range:381-430

特异性

c-Fgr Polyclonal Antibody detects endogenous levels of c-Fgr protein.

基因名称

FGR

蛋白名称

Tyrosine-protein kinase Fgr

别名

FGR;SRC2;Tyrosine-protein kinase Fgr;Gardner-Rasheed feline sarcoma viral;v-fgr;oncogene homolog;Proto-oncogene c-Fgr;p55-Fgr;p58-Fgr;p58c-Fgr

基因ID-1

2268

SwissProt

P09769

背景

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008],

细胞定位

Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Mitochondrion inner membrane . Mitochondrion intermembrane space . Detected in mitochondrial intermembrane space and at inner membranes (By similarity). Colocalizes with actin fibers at membrane ruffles. Detected at plasma membrane lipid rafts. .