CLK2 Polyclonal Antibody

产品详情

产品名称

CLK2 Polyclonal Antibody

产品货号

YM-A17605

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,IHC,IF,ELISA

分子量

60kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human CLK2. AA range:1-50

特异性

CLK2 Polyclonal Antibody detects endogenous levels of CLK2 protein.

基因名称

CLK2

蛋白名称

Dual specificity protein kinase CLK2

别名

CLK2;Dual specificity protein kinase CLK2;CDC-like kinase 2

基因ID-1

1196

SwissProt

P49760

背景

CDC like kinase 2(CLK2) Homo sapiens This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014],

细胞定位

Nucleus .; [Isoform 1]: Nucleus . Nucleus speckle . Inhibition of phosphorylation at Ser-142 results in accumulation in the nuclear speckle. .; [Isoform 2]: Nucleus speckle . Co-localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles. .