COL18A1 Polyclonal Antibody

产品详情

产品名称

COL18A1 Polyclonal Antibody

产品货号

YM-A17641

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

IHC,IF,ELISA

分子量

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human Collagen alpha1 XVIII. AA range:1301-1350

特异性

COL18A1 Polyclonal Antibody detects endogenous levels of COL18A1 protein.

基因名称

COL18A1

蛋白名称

Collagen alpha-1(XVIII) chain

别名

COL18A1;Collagen alpha-1;XVIII;chain

基因ID-1

80781

SwissProt

P39060

背景

This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],

细胞定位

Secreted, extracellular space, extracellular matrix . Secreted, extracellular space, extracellular matrix, basement membrane .; [Non-collagenous domain 1]: Secreted, extracellular space, extracellular matrix, basement membrane . Secreted .; [Endostatin]: Secreted . Secreted, extracellular space, extracellular matrix, basement membrane .