CYP21A2 Polyclonal Antibody

产品详情

产品名称

CYP21A2 Polyclonal Antibody

产品货号

YM-A17799

规格

50μL;100μL

种属反应

Human

实验应用

WB,ELISA

分子量

55kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;ELISA 1:40000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from the Internal region of human CYP21A2.

特异性

CYP21A2 Polyclonal Antibody detects endogenous levels of CYP21A2 protein.

基因名称

CYP21A2

蛋白名称

Steroid 21-hydroxylase

别名

CYP21A2;CYP21;CYP21B;Steroid 21-hydroxylase;21-OHase;Cytochrome P-450c21;Cytochrome P450 21;Cytochrome P450 XXI;Cytochrome P450-C21;Cytochrome P450-C21B

基因ID-1

1589

SwissProt

P08686

背景

cytochrome P450 family 21 subfamily A member 2(CYP21A2) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene; gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

细胞定位

Endoplasmic reticulum membrane; Peripheral membrane protein . Microsome membrane ; Peripheral membrane protein .