CYP2C19 Polyclonal Antibody

产品详情

产品名称

CYP2C19 Polyclonal Antibody

产品货号

YM-A17812

规格

50μL;100μL

种属反应

Human

实验应用

WB,IHC,IF,ELISA

分子量

56kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:5000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human Cytochrome P450 2C19. AA range:241-290

特异性

CYP2C19 Polyclonal Antibody detects endogenous levels of CYP2C19 protein.

基因名称

CYP2C19

蛋白名称

Cytochrome P450 2C19

别名

CYP2C19;Cytochrome P450 2C19;R;-limonene 6-monooxygenase;S;-limonene 6-monooxygenase;S;-limonene 7-monooxygenase;CYPIIC17;CYPIIC19;Cytochrome P450-11A;Cytochrome P450-254C;Mephenytoin 4-hydroxylase

基因ID-1

1557

SwissProt

P33261

背景

cytochrome P450 family 2 subfamily C member 19(CYP2C19) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008],

细胞定位

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.