CYP2D6 Polyclonal Antibody

产品详情

产品名称

CYP2D6 Polyclonal Antibody

产品货号

YM-A17816

规格

50μL;100μL

种属反应

Human

实验应用

WB,IHC,IF,ELISA

分子量

55kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human Cytochrome P450 2D6. AA range:251-300

特异性

CYP2D6 Polyclonal Antibody detects endogenous levels of CYP2D6 protein.

基因名称

CYP2D6

蛋白名称

Cytochrome P450 2D6

别名

CYP2D6;CYP2DL1;Cytochrome P450 2D6;CYPIID6;Cytochrome P450-DB1;Debrisoquine 4-hydroxylase

基因ID-1

1565

SwissProt

P10635

背景

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in

细胞定位

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane ; Peripheral membrane protein.