CYP8B1 Polyclonal Antibody

产品详情

产品名称

CYP8B1 Polyclonal Antibody

产品货号

YM-A17839

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,IHC,IF,ELISA

分子量

58kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:40000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human Cytochrome P450 8B1. AA range:371-420

特异性

CYP8B1 Polyclonal Antibody detects endogenous levels of CYP8B1 protein.

基因名称

CYP8B1

蛋白名称

7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase

别名

CYP8B1;CYP12;7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase;7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase;CYPVIIIB1;Cytochrome P450 8B1;Sterol 12-alpha-hydroxylase

基因ID-1

1582

SwissProt

Q9UNU6

背景

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it is intronless. [provided by RefSeq, Jul 2008],

细胞定位

Endoplasmic reticulum membrane ; Single-pass membrane protein . Microsome membrane ; Single-pass membrane protein .