Dsg1 Polyclonal Antibody

产品详情

产品名称

Dsg1 Polyclonal Antibody

产品货号

YM-A17998

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,ELISA

分子量

114kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;ELISA 1:40000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human DSG1. AA range:161-210

特异性

Dsg1 Polyclonal Antibody detects endogenous levels of Dsg1 protein.

基因名称

DSG1

蛋白名称

Desmoglein-1

别名

DSG1;CDHF4;Desmoglein-1;Cadherin family member 4;Desmosomal glycoprotein 1;DG1;DGI;Pemphigus foliaceus antigen

基因ID-1

1828

SwissProt

Q02413

背景

This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015],

细胞定位

Cell membrane ; Single-pass type I membrane protein . Cell junction, desmosome.