HAND1 Polyclonal Antibody

产品详情

产品名称

HAND1 Polyclonal Antibody

产品货号

YM-A18059

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

IF,ELISA

分子量

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications;

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human HAND1. AA range:141-190

特异性

HAND1 Polyclonal Antibody detects endogenous levels of HAND1 protein.

基因名称

HAND1

蛋白名称

Heart- and neural crest derivatives-expressed protein 1

别名

HAND1;BHLHA27;EHAND;Heart- and neural crest derivatives-expressed protein 1;Class A basic helix-loop-helix protein 27;bHLHa27;Extraembryonic tissues;heart, autonomic nervous system and neural crest derivatives-expressed protein 1;eH

基因ID-1

9421

SwissProt

O96004

背景

The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008],

细胞定位

Nucleus, nucleoplasm . Nucleus, nucleolus . Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity (By similarity). .