GTBP Polyclonal Antibody

产品详情

产品名称

GTBP Polyclonal Antibody

产品货号

YM-A18556

规格

50μL;100μL

种属反应

Human,Mouse,Monkey

实验应用

WB,IHC,IF,ELISA

分子量

170kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human MSH6. AA range:341-390

特异性

GTBP Polyclonal Antibody detects endogenous levels of GTBP protein.

基因名称

MSH6

蛋白名称

DNA mismatch repair protein Msh6

别名

MSH6;GTBP;DNA mismatch repair protein Msh6;hMSH6;G/T mismatch-binding protein;GTBP;GTMBP;MutS-alpha 160 kDa subunit;p160

基因ID-1

2956

SwissProt

P52701

背景

This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013],

细胞定位

Nucleus . Chromosome . Associates with H3K36me3 via its PWWP domain.