HLA-DOα Polyclonal Antibody

产品详情

产品名称

HLA-DOα Polyclonal Antibody

产品货号

YM-A18625

规格

50μL;100μL

种属反应

Human

实验应用

WB,IHC,IF,ELISA

分子量

34kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:40000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human HLA-DOA. AA range:71-120

特异性

HLA-DOα Polyclonal Antibody detects endogenous levels of HLA-DOα protein.

基因名称

HLA-DOA

蛋白名称

HLA class II histocompatibility antigen DO alpha chain

别名

HLA-DOA;HLA-DNA;HLA-DZA;HLA class II histocompatibility antigen;DO alpha chain;MHC DN-alpha;MHC DZ alpha;MHC class II antigen DOA

基因ID-1

3111

SwissProt

P06340

背景

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008],

细胞定位

Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.