HURP Polyclonal Antibody

产品详情

产品名称

HURP Polyclonal Antibody

产品货号

YM-A18696

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,ELISA

分子量

95kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;ELISA 1:40000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human DLGAP5. AA range:791-840

特异性

HURP Polyclonal Antibody detects endogenous levels of HURP protein.

基因名称

DLGAP5

蛋白名称

Disks large-associated protein 5

别名

DLGAP5;DLG7;KIAA0008;Disks large-associated protein 5;DAP-5;Discs large homolog 7;Disks large-associated protein DLG7;Hepatoma up-regulated protein;HURP

基因ID-1

9787

SwissProt

Q15398

背景

developmental stage:Elevated levels of expression detected in the G2/M phase of synchronized cultures of HeLa cells.,function:Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR. Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells.,PTM:Ubiquitinated, leading to its degradation.,similarity:Belongs to the SAPAP family.,subcellular location:Localizes to the spindle poles in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.,subunit:Interacts with CDC2. Interacts with the C-terminal proline-rich region of FBXO7. Recruited by FBXO7 to a SCF (SKP1-CUL1-F-box) protein complex in a CDC2/Cyclin B-phosphorylation dependent manner. Interacts with CDH1.,tissue specificity:Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta.,

细胞定位

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.