KCNH1 Polyclonal Antibody

产品详情

产品名称

KCNH1 Polyclonal Antibody

产品货号

YM-A18833

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,ELISA,IHC

分子量

110kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human KCNH1. AA range:720-769

特异性

KCNH1 Polyclonal Antibody detects endogenous levels of KCNH1 protein.

基因名称

KCNH1

蛋白名称

Potassium voltage-gated channel subfamily H member 1

别名

KCNH1;EAG;EAG1;Potassium voltage-gated channel subfamily H member 1;Ether-a-go-go potassium channel 1;EAG channel 1;h-eag;hEAG1;Voltage-gated potassium channel subunit Kv10.1

基因ID-1

3756

SwissProt

O95259

背景

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided

细胞定位

Cell membrane ; Multi-pass membrane protein . Nucleus inner membrane ; Multi-pass membrane protein . Cell projection, dendrite . Cell projection, axon . Cell junction, synapse, presynaptic cell membrane . Perikaryon . Cell junction, synapse, postsynaptic density membrane . Early endosome membrane . Perinuclear KCNH1 is located to NPC-free islands.