Manic Fringe Polyclonal Antibody

产品详情

产品名称

Manic Fringe Polyclonal Antibody

产品货号

YM-A18993

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,ELISA

分子量

38kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;ELISA 1:5000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human MFNG. AA range:61-110

特异性

Manic Fringe Polyclonal Antibody detects endogenous levels of Manic Fringe protein.

基因名称

MFNG

蛋白名称

Beta-1,3-N-acetylglucosaminyltransferase manic fringe

别名

MFNG;Beta-1;3-N-acetylglucosaminyltransferase manic fringe;O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

基因ID-1

4242

SwissProt

O00587

背景

This gene is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. [provided by RefSeq, Oct 2009],

细胞定位

Golgi apparatus membrane ; Single-pass type II membrane protein .