Melan-A Polyclonal Antibody

产品详情

产品名称

Melan-A Polyclonal Antibody

产品货号

YM-A19068

规格

50μL;100μL

种属反应

Human

实验应用

WB,IHC,IF,ELISA

分子量

15kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:40000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human MART-1. AA range:41-90

特异性

Melan-A Polyclonal Antibody detects endogenous levels of Melan-A protein.

基因名称

MLANA

蛋白名称

Melanoma antigen recognized by T-cells 1

别名

MLANA;MART1;Melanoma antigen recognized by T-cells 1;MART-1;Antigen LB39-AA;Antigen SK29-AA;Protein Melan-A

基因ID-1

2315

SwissProt

Q16655

背景

tissue specificity:Expression is restricted to melanoma and melanocyte cell lines and retina.,

细胞定位

Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.