mGluR-2/3 Polyclonal Antibody

产品详情

产品名称

mGluR-2/3 Polyclonal Antibody

产品货号

YM-A19079

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,IHC,IF,ELISA

分子量

100kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human mGluR2/3. AA range:823-872

特异性

mGluR-2/3 Polyclonal Antibody detects endogenous levels of mGluR-2/3 protein.

基因名称

GRM2

蛋白名称

Metabotropic glutamate receptor 2

别名

GRM2;GPRC1B;MGLUR2;Metabotropic glutamate receptor 2;mGluR2;GRM3;GPRC1C;MGLUR3;Metabotropic glutamate receptor 3;mGluR3

基因ID-1

2912;2913

SwissProt

Q14416;Q14832

背景

glutamate metabotropic receptor 2(GRM2) Homo sapiens L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene

细胞定位

Cell membrane; Multi-pass membrane protein. Cell junction, synapse . Cell projection, dendrite .