ML-IAP Polyclonal Antibody

产品详情

产品名称

ML-IAP Polyclonal Antibody

产品货号

YM-A19115

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,IHC

分子量

21kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-2000;IHC 1:50-300

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human ML-IAP. AA range:162-211

特异性

ML-IAP Polyclonal Antibody detects endogenous levels of ML-IAP protein.

基因名称

BIRC7

蛋白名称

Baculoviral IAP repeat-containing protein 7

别名

BIRC7;KIAP;LIVIN;MLIAP;RNF50;Baculoviral IAP repeat-containing protein 7;Kidney inhibitor of apoptosis protein;KIAP;Livin;Melanoma inhibitor of apoptosis protein;ML-IAP;RING finger protein 50

基因ID-1

79444

SwissProt

Q96CA5

背景

This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jul 2013],

细胞定位

Nucleus . Cytoplasm . Golgi apparatus . Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively in the cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis.