MLKL Polyclonal Antibody

产品详情

产品名称

MLKL Polyclonal Antibody

产品货号

YM-A19121

规格

50μL;100μL

种属反应

Human

实验应用

WB,IHC

分子量

55kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-2000;IHC 1:50-300

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from MLKL . at AA range: 40-120

特异性

MLKL Polyclonal Antibody detects endogenous levels of MLKL protein.

基因名称

MLKL

蛋白名称

Mixed lineage kinase domain-like protein

别名

MLKL;Mixed lineage kinase domain-like protein

基因ID-1

197259

SwissProt

Q8NB16

背景

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],

细胞定位

Cytoplasm . Cell membrane . Nucleus . Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671). Localizes to the nucleus in response to orthomyxoviruses infection (By similarity). .