MPP1 Polyclonal Antibody

产品详情

产品名称

MPP1 Polyclonal Antibody

产品货号

YM-A19151

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

IF,ELISA,IHC

分子量

210kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

IF/ICC1:50-300;ELISA 1:2000-20000;IHC 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human KIF20B. AA range:1771-1820

特异性

MPP1 Polyclonal Antibody detects endogenous levels of MPP1 protein.

基因名称

KIF20B

蛋白名称

Kinesin-like protein KIF20B

别名

KIF20B;KRMP1;MPHOSPH1;Kinesin-like protein KIF20B;Cancer/testis antigen 90;CT90;Kinesin-related motor interacting with PIN1;M-phase phosphoprotein 1;MPP1

基因ID-1

9585

SwissProt

Q96Q89

背景

KIF20B (Kinesin Family Member 20B) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF23.

细胞定位

Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Nucleus, nucleolus . Nucleus, nucleoplasm . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, spindle pole . Midbody . Cell projection, axon . Cell projection, growth cone . Localizes mainly in the nucleus during interphase although it is also detected in the cytoplasm without clear association with microtubules (PubMed:12740395). Localized to the central spindle during cytokinetic furrowing and with the midbody during abscission (PubMed:12740395, PubMed:17409436). A 2-3 fold expression increase is seen as cells progress from G1 to G2/M phase (PubMed:12740395). During prophase and metaphase it is found throughout the cytoplasm and at anaphase accumulates at the midplan of the cell and forms a distinct band extending across the spindle midzone (PubMed:12740395). At anaphase it is concentrated in the midbody (PubMed:12740395). Colocalized partially along microtubules in primary neurons. Colocalized with SHTN1 along microtubules to the tip of the growing cone in primary hippocampal neurons. Localized in midbodies between dividing radial progenitors in the ventricular zone (By similarity). Colocalized with PRC1 in the nucleus of bladder carcinoma cells at the interphase. Colocalized with PRC1 in bladder carcinoma cells at prophase, metaphase, early anaphase, at the midzone in late anaphase and at the contractile ring in telophase (PubMed:17409436). .