MRCKα Polyclonal Antibody

产品详情

产品名称

MRCKα Polyclonal Antibody

产品货号

YM-A19155

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,ELISA,IHC

分子量

200kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from the Internal region of human MRCKα. AA range: 580-660

特异性

MRCKα Polyclonal Antibody detects endogenous levels of MRCKα protein.

基因名称

CDC42BPA

蛋白名称

Serine/threonine-protein kinase MRCK alpha

别名

CDC42BPA;KIAA0451;Serine/threonine-protein kinase MRCK alpha;CDC42-binding protein kinase alpha;DMPK-like alpha;Myotonic dystrophy kinase-related CDC42-binding kinase alpha;MRCK alpha;Myotonic dystrophy protein kinase-like alpha

基因ID-1

8476

SwissProt

Q5VT25

背景

The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq, Jul 2008],

细胞定位

Cytoplasm . Cell projection, lamellipodium . Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent. Localizes in the lamellipodium in a FAM89B/LRAP25-dependent manner. .