Sin3B Polyclonal Antibody

产品详情

产品名称

Sin3B Polyclonal Antibody

产品货号

YM-A19224

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,ELISA,IHC

分子量

130kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human SIN3B. AA range:221-270

特异性

Sin3B Polyclonal Antibody detects endogenous levels of Sin3B protein.

基因名称

SIN3B

蛋白名称

Paired amphipathic helix protein Sin3b

别名

SIN3B;KIAA0700;Paired amphipathic helix protein Sin3b;Histone deacetylase complex subunit Sin3b;Transcriptional corepressor Sin3b

基因ID-1

23309

SwissProt

O75182

背景

function:Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription.,similarity:Contains 3 PAH (paired amphipathic helix) repeats.,subunit:Interacts with FOXK1/MNF, MXI, MAD, NCOR1 and SAP30. Interaction with SDS3 enhances the interaction with HDAC1 to form a complex. Interacts with MAD3, MAD4, MAEL, REST and SETDB1 (By similarity). Interacts with HCFC1.,

细胞定位

Nucleus .