Myosin IXb Polyclonal Antibody

产品详情

产品名称

Myosin IXb Polyclonal Antibody

产品货号

YM-A19260

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,ELISA,IHC

分子量

250kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human MYO9B. AA range:304-353

特异性

Myosin IXb Polyclonal Antibody detects endogenous levels of Myosin IXb protein.

基因名称

MYO9B

蛋白名称

Unconventional myosin-IXb

别名

MYO9B;MYR5;Unconventional myosin-IXb;Unconventional myosin-9b

基因ID-1

4650

SwissProt

Q13459

背景

This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],

细胞定位

Cytoplasm, cell cortex . Cytoplasm, perinuclear region . Cytoplasm, cytoskeleton . In undifferentiated cells colocalizes with F-actin in the cell periphery while in differentiated cells its localization is cytoplasmic with the highest levels in the perinuclear region. .