Neddylin Polyclonal Antibody

产品详情

产品名称

Neddylin Polyclonal Antibody

产品货号

YM-A19331

规格

50μL;100μL

种属反应

Human,Mouse,Rat,Monkey

实验应用

WB,IHC,IF,ELISA

分子量

9kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:5000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human NEDD8. AA range:10-59

特异性

Neddylin Polyclonal Antibody detects endogenous levels of Neddylin protein.

基因名称

NEDD8

蛋白名称

NEDD8

别名

NEDD8;NEDD8;Neddylin;Neural precursor cell expressed developmentally down-regulated protein 8;NEDD-8;Ubiquitin-like protein Nedd8

基因ID-1

4738

SwissProt

Q15843

背景

function:Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.,PTM:Cleavage of precursor form by UCHL3 or SENP8 is necessary for function.,similarity:Belongs to the ubiquitin family.,subcellular location:Mainly nuclear.,subunit:Directly interacts with NUB1 and AHR. Covalently attached to cullins and p53.,tissue specificity:Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes.,

细胞定位

Nucleus . Mainly nuclear. .