Neurexin I Polyclonal Antibody

产品详情

产品名称

Neurexin I Polyclonal Antibody

产品货号

YM-A19354

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,IHC

分子量

150kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-2000;IHC 1:50-300

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human NRXN1. AA range:502-551

特异性

Neurexin I Polyclonal Antibody detects endogenous levels of Neurexin I protein.

基因名称

NRXN1

蛋白名称

Neurexin-1-alpha

别名

NRXN1;KIAA0578;Neurexin-1-alpha;Neurexin I-alpha

基因ID-1

9378

SwissProt

Q9ULB1

背景

NRXN1 (neurexin 1) encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for NRXN1 in the 3' region. Mutations in NRXN1 are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia.

细胞定位

Cell junction, synapse, presynaptic cell membrane ; Single-pass type I membrane protein .